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As this may sound unpleasant and any side-effect is, keep in mind, all medications, steroidal and non-steroidal alike carry with them the possibility of adverse reactions. The most common possible side-effects include: Testicular Atrophy Water Retention Gynecomastia High Blood Pressure Acne Adverse Cholesterol Reactions. Of these side-effects only one is certain and it is testicular atrophy; yes, if you are a male and you use exogenous testosterone your testicles will shrink; however, once you discontinue use they will return to their normal size. There is a very simple explanation for this occurrence; our natural testosterone is produced in the testicles, once outside testosterone is introduced into the body our testicles no longer have a need to produce any testosterone and therefore shrink. Once use is discontinued and natural testosterone production begins again our testicles will return to their previous state. 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