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Composition Dosage Form Pharmacology Indications Dosage and Administration Contraindications Warnings and Precautions Undesirable Effects Overdosage Shelf-Life Storage and handling instructions Packaging Information. Each film-coated tablet contains: Anastrozole IP ”””. Anastrozole is a potent and highly selective non-steroidal aromatase inhibitor. In postmenopausal women, oestradiol is produced primarily from the conversion of androstenedione to oestrone through the aromatase enzyme complex in peripheral tissues. Oestrone is subsequently converted to oestradiol. Reducing circulating oestradiol levels has been shown to produce a beneficial effect in women with breast cancer. In postmenopausal women, anastrozole at a daily dose of 1 mg produced oestradiol suppression of greater than 80%, using a highly sensitive assay. Anastrozole does not possess any progestogenic, androgenic or oestrogenic activity, but does perturb the circulating levels of progesterone, androgens and oestrogens. Daily doses of anastrozole up to 10 mg do not have any effect on cortisol or aldosterone secretion, measured before or after standard adrenocorticotrophic hormone (ACTH) challenge testing. Corticoid supplements are, therefore, not needed. Inhibition of aromatase activity is primarily due to anastrozole, the parent drug. Absorption of anastrozole is rapid and maximum plasma concentrations typically occur within 2 hours of dosing under fasted conditions. Studies with radiolabelled drug have demonstrated that orally administered anastrozole is well absorbed into the systemic circulation. Food reduces the rate but not the overall extent of anastrozole absorption, turinabol. 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