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Nolvadex treatment was associated with a 50% reduction in frequency of vaginal bleeding episodes by patient or family report (mean annualized frequency of 3. Among the patients who reported vaginal bleeding during the pre-study period, 62% (13 out of 21 patients) reported no bleeding for a 6-month period and 33% (7 out of 21 patients) reported no vaginal bleeding for the duration of the trial. Not all patients improved on treatment and a few patients not reporting vaginal bleeding in the 6 months prior to enrollment reported menses on treatment. Nolvadex therapy was associated with a reduction in mean rate of increase of bone age. Individual responses with regard to bone age advancement were highly heterogeneous. Linear growth rate was reduced during the course of Nolvadex treatment in a majority of patients (mean change of 1. This change was not uniformly seen across all stages of bone maturity; all recorded response failures occurred in patients with bone ages less than 7 years at screening. Mean uterine volume increased after 6 months of treatment and doubled at the end of the one-year study. A causal relationship has not been established; however, as an increase in the incidence of endometrial adenocarcinoma and uterine sarcoma has been noted in adults treated with Nolvadex (see BOXED WARNING ), continued monitoring of McCune-Albright patients treated with Nolvadex for long-term uterine effects is recommended. The safety and efficacy of Nolvadex for girls aged two to 10 years with McCune-Albright Syndrome and precocious puberty have not been studied beyond one year of treatment. The long-term effects of Nolvadex therapy in girls have not been established. Indications and Usage for Nolvadex. Metastatic Breast Cancer: Nolvadex is effective in the treatment of metastatic breast cancer in women and men. 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Most, but not all, breast cancers are sensitive to oestrogen and are known as oestrogen receptor-positive because they are oestrogen-dependent tumours and the cells contain oestrogen receptors. Raloxifene in Evista tablets 60mg has anti-oestrogenic in breast tissue which means that although it binds to the oestrogen receptor on tumour cells, it does not stimulate cell growth. Evista tablets 60mg are used to reduce the risk of invasive breast cancers, a tumour that is oestrogen-dependent and has receptors for oestrogen, in postmenopausal women with osteoporosis and in women at high risk of invasive breast cancer. What are the side effects of Evista? Most of the commonly reported side effects when using Evista tablets 60mg include: hot flushes, leg cramp, fluid retention (oedema) causing swelling of hands, feet and legs, skin rash. 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Description of the drug: Raloxifene belongs to a category of drug known as Selective Estrogen Receptor Modulator (SERM). This drug acts as an estrogen agonist/antagonist and is highly prescribed for the treatment of Osteoporosis (thinning of bone). Raloxifene is very effective to treat the problem of decreasing bone density, especially in women with post menopause. Indications and Usage: Raloxifene modulates the working of estrogen receptors. This drug prevents the high risk of bone breakdown and thinning that usually occurs in women after menopausal. It also prevents the occurrence of invasive breast cancer by inhibiting the estrogen receptors in uterus in breast. Raloxifene can however elevate serious problem of blood clot formation. It may also enhance the occurrence of strokes in people suffering from coronary heart disease. Dosage and administration: -Recommended Dosage: The recommended dose of this drug for adults is 60 mg once every day. 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