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Daily doses of prednisone, however, reduced KLF15, leading to muscle wasting. In the study, normal mice with a muscle injury received steroids just before injury and for two weeks after the injury. Mice receiving two weekly doses of steroids after the injury performed better on treadmill testing and had stronger muscle than mice receiving a placebo. Mice that received daily steroids for two weeks after the muscle injury performed poorly on the treadmill and in muscle strength studies, compared to placebo-treated mice. Scientists also tested the drug in a mouse model of muscular dystrophy, since prednisone is normally given for this disease. Mice with muscular dystrophy that received weekly prednisone were stronger and performed better on the treadmill than those that received a placebo. When prednisone was given every day, the muscles atrophied and wasted. McNally, also a professor of Medicine in the Division of Cardiology and of Biochemistry and Molecular Genetics, initiated the research because she wanted to understand how prednisone ‘ which is given to treat individuals with a form of muscular dystrophy called Duchenne Muscular Dystrophy ‘ prolongs patients’ ability to walk independently and stay out of a wheelchair. Only boys get Duchenne Muscular Dystrophy because it is on the X chromosome, and males have only one X chromosome. This technique uses a laser to poke a hole in muscle cells. Then the muscle cell is observed in real time as it reseals the hole, a natural repair process. Next, the scientists tested to see if steroids could boost the repair process. They damaged the leg muscles in mice and noticed the mice receiving the steroids recovered more rapidly from injury. Her work also implies normal muscle injury would improve more quickly by taking a weekly dose of steroids such as prednisone. 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