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It will depend upon the indication for use, the age and weight of the patient, and the doctor’s preference. The dose for induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is sec ondary and not due to primary ovarian failure and who has been appropriately pretreated with human menotropins is 5,000 to 10,000 USP units one day following the last dose of menotropins. Storage Instructions for HCG Injections. Each vial of Human Chorionic Gonadotropin Injection (HCG Shot) is sold along with a vial of sterile diluent containing 30 mL of bacteriostatic water for Injection USP, containing 0. Store dry product at 20’C to 25’C (68’F to 77’F), excursions permitted between 15’C and 30’C (between 59’F and 86’F) Human Chorionic Gonadotropin Injection Contraindications, ht leopard m1t pedal. Human Chorionic Gonadotropin Injection are contraindicated in patients with Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm, prior allergic reaction to HCG. HCG can cause fetal harm when administered to a pregnant woman. Combined treatment with HCG/PMS (pregnant mare’s serum) has been observed to cause high incidences of external congenital anomalies in the offspring of mice, in a dose-dependent manner. Human Chorionic Gonadotropin Injection Side Effects. The possible side effects of Human Chorionic Gonadotropin injection include Headache, irritability, restlessness, depression, fatigue, edema, precocious puberty, gynecomastia, pain at the site of injection. Hypersensitivity reactions both localized and systemic in nature, including erythema, urticaria, rash, angioedema, dyspnea and shortness of breath, have been reported. The relationship of these allergic-like events to the polypeptide hormone or the diluent containing benzyl alcohol is not clear. Warnings and Precautions When Using HCG Injection. The precautions are as follows: General Precautions: 1. Induction of androgen secretion by HCG may induce precocious puberty in patients treated for cryptorchidism. Therapy should be discontinued if signs of precocious puberty occur. Since androgens may cause fluid retention, HCG shots should be used with caution in patients with cardiac or renal disease, epilepsy, migraine, or asthma. Carcinogenesis, Mutagenesis, Impairment of Fertility: There have been sporadic reports of testicular tumors in otherwise healthy young men receiving HCG injections for secondary infertility. A causative relationship between HCG and tumor development in these men has not been established. Warnings: HCG injection should be used in conjunction with human menopausal gonadotropins only by physicians experienced with infertility problems who are familiar with the criteria for patient selection, contraindications, warnings, precautions, and side effects described for menotropins. The principal serious adverse reactions during this use are: (1) Ovarian hyperstimulation, a syndrome of sudden ovarian enlargement, ascites with or without pain, and/or pleural effusion; (2) Enlargement of preexisting ovarian cysts or rupture of ovarian cysts with resultant hemoperitoneum; (3) Multiple births, and (4) Arterial thromboembolism. The acute toxicity of urinary gonadotropin medications has been shown to be very low. Despite this, there exists a possibility that too high a dosage of hCG can lead to ovarian hyperstimulation syndrome. Human Chorionic Gonadotropin Injection During Pregnancy. Human Chorionic Gonadotropin Injection has been classified by the US FDA as Pregnancy Category X.
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