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Common Adverse Reactions In Placebo-Controlled Studies. The number of patients receiving multiple doses of Effexor XR during the premarketing assessment for each approved indication is shown in Table 8. The conditions and duration of exposure to venlafaxine in all development programs varied greatly, and included (in overlapping categories) open and double-blind studies, uncontrolled and controlled studies, inpatient (Effexor only) and outpatient studies, fixed-dose, and titration studies. Table 8: Patients Receiving Effexor XR in Premarketing Clinical Studies Indication Effexor XR MDD 705 a GAD 1,381 SAD 819 PD 1,314 a In addition, in the premarketing assessment of Effexor, multiple doses were administered to 2,897 patients in studies for MDD. 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Across most indications, a dose-related increase in mean supine systolic and diastolic blood pressure was evident in patients treated with Effexor XRs. Across all clinical studies in MDD, GAD, SAD and PD, 1. Similarly, 1% of patients in the Effexor XR groups experienced an increase in SSBP of ? 20 mm Hg with a blood pressure ? 180 mm Hg, compared to 0. Table 10: Final On-therapy Mean Changes From Baseline in Supine Systolic (SSBP) and Diastolic (SDBP) Blood Pressure (mm Hg) in Placebo-controlled Studies Indication (Duration) Effexor XR Placebo ? 75 mg per day > 75 mg per day SSBP SDBP SSBP SDBP SSBP SDBP MDD (8-12 weeks) -0. 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