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According to the results, after the administration of CJC-1295, there was a dose-dependent increase in GH and IGF-I levels (IGF-1: Insulin-like growth factor 1- is a hormone similar to insulin which plays a significant role during childhood on the growth, and has anabolic effects in adults) among the participants and no serious adverse effects were reported [7]. In 2006, another group of scientists assessed the GH pulsatility after a single injection of CJC-1295. They found out that there is an increase of about 50% in GH secretion and IGF-I levels after the injection of CJC-1295. Moreover, and in concordance with the previously mentioned study, none of the subjects experienced any adverse effects [8]. In addition to the human studies that took place, additional animal studies were conducted to evaluate the efficacy of CJC-1295. An interesting study was conducted using mice and a drug or placebo was injected. The researchers concluded that once-daily injections of 2 ?g of CJC-1295 can completely normalize growth. Another finding was that administration of the same dose of CJC-1295 every 2 or 3 days produced intermediate results, indicating an interval-dependent effect [9]. What are its side effects? As mentioned earlier in the analysis of related studies, there were no serious adverse effects noticed during the studies. Of course, the administered dose, the duration, and the frequency are matters that play a crucial role when talking about side effects. Therefore, only when using the same doses, frequency, and duration of treatment can we be sure about its safety. Specifically, in the study of Teichman and colleagues (2006) there were no significant increases in other hormones, including prolactin, LH levels, serum cortisol, and TSH after a single injection of CJC-1295 (60 ?g/kg) which confirms the specificity of CJC-1295 for GH secretion. According to the researchers of the study, all the adverse effects were of mild to moderate severity that didn’t require any medical intervention to resolve. The most common adverse effects noticed were the injection site reactions including itching, pain, irritation, erythema, and induration that occurred transiently in 7 out of 10 of the subjects receiving CJC-1295 and rarely in the ones receiving placebo. It is worth mentioning that the injection site reactions were more severe and/or prolonged after higher doses. About 1/3 of the participants experienced transient urticarial rashes at the injection site occurred in almost 30% of subjects. Furthermore, actively treated subjects reported headache (in more than 60%), and diarrhea (in less than ? of the subjects). 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