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If administering a strong inducer is necessary, consider managing the patient using paliperidone extended-release tablets [see DOSAGE AND ADMINISTRATION ]. Levodopa and Other Dopamine Agonists Paliperidone may antagonize the effect of levodopa and other dopamine agonists. Monitor and manage patient as clinically appropriate. Drugs Having No Clinically Important Interactions With INVEGA TRINZA ‘ Based on pharmacokinetic studies with oral paliperidone, no dosage adjustment of INVEGA TRINZA ‘ is required when administered concomitantly with valproate [see CLINICAL PHARMACOLOGY ]. Additionally, no dosage adjustment is necessary for valproate when coadministered with INVEGA TRINZA ‘ [see CLINICAL PHARMACOLOGY ]. Pharmacokinetic Interaction Between Lithium And INVEGA TRINZA ‘ Is unlikely. Paliperidone is not expected to cause clinically important pharmacokinetic interactions with drugs that are metabolized by cytochrome P450 isozymes. 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